The influence of placenta partially methylated domains on global epigenetic profiles (MONK_U26DTP)

Are you holding a Master’s degree and looking for a PhD position in the area of developmental epigenetics? As a member of the Norwich Research Park (NRP), the University of East Anglia invites applications for the 2026 BBSRC funded Development Training PhD Programme.

Our previous work has revealed that the human placenta has large partially methylated domains (PMDs) that result in global hypomethylation. This project will address how PMDs influence local gene transcription, enhancer choice and epigenetic responsiveness to developmental cues. The candidate will determine how histone modifications and chromatin looping influence genome function within PMDs by generating global expression, histone and methylation profiles, as well as contact maps in placenta using RNA-seq, methyl-seq, CUT&Tag and hiC approaches. Bioinformatic analysis of the resulting datasets, will help resolve how PMDs function in health and disease.

We are looking for an enthusiastic and ambitious student who is keen to unite both laboratory and computation skills. The project is a joint NRP venture between the groups of Professor David Monk at the University of East Anglia and Dr Wilfried Haerty at the Earlham Institute. In addition to the generic skills training that is provided through the BBSRC NRPDTP programme, the student will be supported by an excellent infrastructure and will work closely with experts in the placental biology and epigenomics. This diverse and stimulating environment allows for the development of key skills in preparation for a successful career in research or industry.

All candidates are strongly advised to contact the PIs to discuss the projects prior to formal application.

https://research-portal.uea.ac.uk/en/persons/david-monk
https://www.earlham.ac.uk/profile/wilfried-haerty