New Kids on the Block – engineering plant immunity for novel disease resistance (BANFIELD_J26DTP)
Like animals, plants get sick, but they have an immune system to fight back against infection. Plant diseases are a threat to food production and a constraint on achieving food security against the background of a changing climate and the need to reduce reliance on fossil fuels. Understanding how the plant immune system works, and how it could be engineered, offers new opportunities to protecting crops and securing high yielding harvests in a sustainable way. A key component of plants’ immune systems are intracellular receptors that detect the presence of pathogen signatures to initiate a reponse.
Recently, a new class of intracellular plant immune receptors, the “tandem kinase proteins” are repeatedly being identified in screens for resistance to disease in important cereal crops like barley and wheat. Several of these new immune receptors contain unusual protein regions that likely directly bind pathogen molecules called “effectors”. Currently, we understand very little about the mechanisms of how these receptor domains bind effectors and how this leads to an immune response. This project will investigate the biochemical, structural, and in planta mechanisms that underpin immune recognition by these proteins, and how they could be engineered to expand or otherwise improve their use in agriculture. Our target for developing new disease resistance is the most devastating fungal disease of cereals, Blast (caused the pathogen Magnaporthe oryzae). The studentship will involve techniques including molecular biology, biochemistry, structural biology, AI-led computational design, in planta assays, and plant pathology. There will opportunities to work with national and international collaborators.
The student will receive expert training in diverse disciplines on a strategically relevant topic, within a stimulating research environment. They will join a team of researchers with shared interests and have access to world-class facilities. Further, it is expected they will attend national/international conferences to present their research.