Investigating molecular mechanisms that regulate abundance and activity of the growth factor PEDF in the retina. (TROEBERG_U26CASE)

Our sense of sight is one of the most important ways we interact with and understand the world around us. The growth factor Pigment Epithelium-Derived Factor (PEDF) is required for the development and maintenance of the mammalian retina, but regulation of its abundance and activity remain poorly understood. This PhD project will address a critical gap in our knowledge by investigating how the localisation, stability, and functional availability of PEDF are regulated. You will investigate how PEDF interacts with components of the extracellular matrix (heparan sulfate proteoglycans, HSPGs) and a cellular scavenger receptor (low-density lipoprotein receptor-related protein, LRP1) to fine-tune its abundance and function within the retina. These regulatory systems are likely to be central to our ability to see, and will also help us understand how complex tissues like the retina organise growth factor signalling in development and adulthood.
As the successful applicant, you will receive interdisciplinary training in protein, molecular, and glycosaminoglycan biology, as well as cell- and tissue-based analyses. You will work across two research groups with complementary expertise: the Troeberg laboratory (post-translational regulation of growth factors) and the Grocott lab (developmental eye biology). You will also complete a placement at Ikarovec, a Norwich Research Park-based biotechnology company interested in PEDF’s role in the retina, where you will gain experience in applying academic discoveries for therapeutic innovation.

This project offers an exciting opportunity to contribute to fundamental questions in molecular and developmental biology, while developing a highly transferable research skillset. Apply now to join a vibrant research environment at UEA and help uncover how growth factor signalling shapes vision. For more information, email us at l.troeberg@uea.ac.uk.