How do RNA molecules shape genome regulation in the nervous system? (AKAY_U26CASE)

This PhD project will investigate how RNA modifications influence the activity of topoisomerase I (TOP1), a crucial enzyme that regulates DNA supercoiling during replication and transcription. Using C. elegans genetics, advanced RNA biology techniques, and industrial biochemistry training with Inspiralis Ltd., the student will investigate how RNAs and their modifications affect topoisomerase activity during C. elegans nervous system development. This multidisciplinary project provides advanced training in molecular genetics, genomics, and translational biotechnology, equipping the student for careers in academia or industry while addressing fundamental questions in RNA biology and health. We offer a multidisciplinary and supportive research environment involving UEA, where the project will be based in Dr Alper Akay’s group (www.theakaylab.com) in collaboration with Earlham Institute (Conrad Nieduszynski – https://www.earlham.ac.uk/profile/conrad-nieduszynski) and Inspiralis Ltd. (https://www.inspiralis.com). The student will receive comprehensive support to learn diverse techniques and engage with both national and international laboratories working on RNA modifications. They will attend conferences at both national and international levels. The student will benefit from internal and external mentorship and career development support. Our RNA (epi)genetics laboratory, funded by a prestigious UK Research and Innovation Future Leaders Fellowship, provides generous resources and advanced instrumentation. This project is particularly suitable for students interested in RNA biology, biochemistry, and Oxford Nanopore sequencing.