Development of new antibacterial compounds in the fight against microbial resistance (SEARCEY_U26DTP)

Antibiotic resistance is a threat to our future. The proliferation of multi-drug resistant bacteria as a result of our overuse of antibiotics means that, one day, even simple surgeries may go back to being prone to deadly infections. We desperately need new antibiotics and to do this we need new targets. DNA is at the centre of all life and we all know it as the double stranded DNA structure but it can also adopt other shapes. One of these is the four way junction (4WJ) and the presence of extended sequences in the bacterial genome called “inverted repeats” suggests that this may be a good target for new antibacterial agents that stabilise or disrupt its formation.

To date, their has been very little work carried out on the formation of 4WJ in the bacterial genome, so we aim to identify sequences that can form these structures and then show that compounds that we have designed and made can stabilise them. We will use a combination of biophysical and biochemical assays to probe these structures and solid and solution phase synthesis to generate new molecules that bind to them. We will study the effects of these compounds on bacteria, using methods developed here at UEA.

This project will develop a multidisciplinary scientist with expertise from chemical to cell biology. You will have, or expect to obtain a first class, 2(i) or equivalent Honours degree in Chemistry, Biochemistry, Pharmacology or a related area.

Informal enquiries are welcomed: Professor Mark Searcey (m.searcey@uea.ac.uk) or Dr Andrew Gates (a.gates@uea.ac.uk).