How do RNA molecules shape genome regulation in the nervous system? (AKAY_U26CASE)

This PhD project will investigate how RNA modifications influence the activity of topoisomerase I (TOP1), a crucial enzyme that regulates DNA supercoiling during replication and transcription.

Biocatalytic Diversification of Complex Natural Products for Enhanced Therapeutic Performance (EL-DEMERDASH_U26CASE)

Many natural products (NPs) show remarkable biological activity, yet their clinical potential is often limited by poor solubility, metabolic instability, or toxicity.

Investigating molecular mechanisms that regulate abundance and activity of the growth factor PEDF in the retina. (TROEBERG_U26CASE)

Our sense of sight is one of the most important ways we interact with and understand the world around us. The growth factor Pigment Epithelium-Derived Factor (PEDF) is required for the development and maintenance of the mammalian retina, but regulation of its abundance and activity remain poorly understood.