The second round of Projects for October 2026 entry are open for applications. For details on the application process, please visit the 'How to apply' page.
This PhD project will investigate how RNA modifications influence the activity of topoisomerase I (TOP1), a crucial enzyme that regulates DNA supercoiling during replication and transcription.
Many natural products (NPs) show remarkable biological activity, yet their clinical potential is often limited by poor solubility, metabolic instability, or toxicity.
Our sense of sight is one of the most important ways we interact with and understand the world around us. The growth factor Pigment Epithelium-Derived Factor (PEDF) is required for the development and maintenance of the mammalian retina, but regulation of its abundance and activity remain poorly understood.