The institutions of the Norwich Research Park offer a range of state-of-the-art facilities to enable our scientists to tackle almost any problem in modern biological research.
Extensive facilities for bioimaging are available at JIC, at QIB and in the Henry Wellcome Laboratory for Cell Imaging at UEA. Together these facilities offer a range of light microscopes, confocal microscopes, transmission and scanning electron microscopes, and atomic force microscopy. Latest additions include a new multi-photon microscope at UEA and a Zeiss super-resolution light microscope and an Andor spinning disc confocal microscope at JIC.
Chris Lamb Training Suite
This facility at JIC provides a resource for integrated training in multidisciplinary biology through a wet laboratory, IT suite/lecture theatre, and discussion/breakout areas including a small garden area. It is used for shorter courses and longer workshops, and also supports other training and staff development activities. The purpose built suite is named in memory of the late Chris Lamb, a former director of JIC (1999-2009).
Full scale field trials for crop geneticists can be carried out at a 115 hectare farm site situated 4 miles from the JIC. The site is presently being equipped with purpose built facilities to support all aspects of field trials work and the necessary storage for modern plot combines and processed seed. In addition a smaller area is available on the main JIC site that includes a GM trial site.
The Earlham Institute (EI) provides expertise and support to NRP scientists utilizing genomics approaches in their research. EI sequencing capability includes a Pacific Biosciences RS single molecule sequencer (PacBio), a Life Technologies Ion Proton, three Illumina MiSeq instruments and five Illumina HiSeq instruments. EI also offers capabilities in Genome mapping through the BioNano Irys instrument. The Bioinformatics division at EI specialises in analysis of high-throughput sequencing data including de novo assemblies, expression analysis (RNA-seq) and metagenomics.
Glasshouses and Controlled Environment Rooms (CERs)
JIC and UEA offer extensive glasshouse facilities. The glasshouses offer computer-controlled environments that allow precise control of the plant environment; length of day, temperature and ventilation. In addition both sites have high-specification containment glasshouses for recombinant plants and pathogens, and DEFRA-controlled plant pests. These are complemented by more than seventy CERs that can control many environmental parameters.
The JIC Entomology Facility is a specialised service that maintains and studies, a wide range of both indigenous and exotic insect species. It is staffed by a team of entomologists who are trained in breeding, handling and evaluating insects. The Insectary supports diverse studies that span insect-plant interactions, plant pathogen-host-vector complexes, natural enemies of pest species and evaluation of crop protection products.
For further information, please visit: http://www.jic.ac.uk/technologies/entomology-insectary.
JIC Metabolite Service can handle narrow targeted, and broad metabolomic approaches using a single quad GC-MS chromatograph, and several liquid chromatography/mass spectrometry (LC-MS) instruments. They have a Xevo triple quad LC-MS, an ion-trap LC-MS, and access to Orbitrap and Q-ToF insturments capable of identifying, quantifying and providing information about chemical structure of metabolites.
Molecular Structure Analysis
JIC has excellent facilities for X-ray crystallography, which are used for routine data collection. Specialist diffraction experiments rely on synchrotron X-ray sources, such as Diamond. JIC also has an 400 MHz NMR spectrometer, used for determining small molecule structures. UEA has an 800 MHz NMR machine (amongst others) used for protein structure/interactions studies. Facilities for other solution-based analyses are available across the NRP.
For further information, please visit: http://www.jic.ac.uk/technologies.
The proteomics facilities at NRP are shared between three institutes; JIC, QIB and TSL. We have a range of instruments including an Orbitrap Fusion, a Synapt G2 QToF and a Xevo triple quadrupole. All of these instruments have both nano-flow and standard-flow liquid chromatography systems and provide robust identification of peptides, their modifications and intact proteins. Facilities include 2-D gel electrophoresis and a MALDI Tof.
For further information, please visit: https://tsl-proteomics.tumblr.com.
Wolfson Fermentation & Bioenergy Laboratory
This Laboratory at UEA is a containment level 2 facility that contains a range of large-scale bioreactors (15-200 litres) and downstream processing facilities, they enable large-scale purification of proteins or metabolites from a range of microorganisms. The facility also houses a number of state-of-the-art continuous culture bioreactors for use in post-genomic studies on microbial physiology.
For further information, please visit: http://www.uea.ac.uk/biological-sciences/research/facilities.