How do antibiotics affect the human gut microbiota?


This PhD studentship provides an exciting opportunity for the successful candidate to address fundamental questions on the role of antibiotics on the gut microbiota and acquire state-of-the art in both in silico and in vivo approaches.

The human body harbours a diverse and dense population of commensal bacteria which exert key functions in terms of human health. Antibiotics remain the major treatment for bacterial infections but also affect the composition of the human gut microbiota with potential side-effects. It is therefore critical to understand the precise mechanisms of how antibiotics may affect the transient shifts in microbial communities, recovery process of the gut microbiome, and mechanisms driving outgrowth or loss of bacterial species during/post antibiotic treatment.

The PhD student will be based at the Quadram Institute Bioscience where he/she will receive training in relevant experimental models and state-of-the art bioinformatics tools for the analysis of gut microbiota communities and benefit from complementary expertise un computational modelling approaches at the Earlham Institute.

The student will benefit from the established network of international collaborations of the host Labs in these this research area. Training will embrace research practice and theory, management, communication (to scientific and lay audiences), intellectual property, teamwork and technical writing. The student will present his/her work to internal seminars and to relevant Microbiology International meetings. The possible commercial issues relating to the impact of this research on human health will be highlighted and the student will be encouraged to participate into outreach activities and innovative competitions.