Gut microbial metabolism at the mucosal surface


The human body harbours a diverse and dense population of commensal bacteria, which exerts key functions in terms of nutrition and health. However, the precise mechanisms of how our resident intestinal microbes maintain a beneficial relationship with the host remain largely unknown, impeding efforts to manipulate dysbiosis microbial communities towards stability and health.

In this project, you will use an interdisciplinary approach to decipher microbial mechanisms and key metabolites that shape the composition of the gut microbiota at the mucosal surface. This PhD project will provide fundamental insights into the metabolic bacterial interactions occurring in the gut and help rationally design symbiotic based strategies to promote human health. The PhD student will join a dynamic Group working in the area of gut bacteria-host interaction at the Quadram Institute Bioscience.

The PhD student will receive expert training in bioinformatics, anaerobic microbiology, molecular and chemical biology and biochemistry. The student will benefit from the established network of international collaborations of the host lab in these this research area. Training will embrace research practice and theory, management, communication (to scientific and lay audiences), intellectual property, teamwork and technical writing. The student will present his/her work to internal seminars and to relevant Microbiology International meetings. The possible commercial issues relating to the impact of this research on human health will be highlighted and the student will be encouraged to participate into outreach activities and innovative competitions.