Development of the face

GRIFFIN_U20DTP

Applications are invited from motivated and ambitious candidates to join a cutting-edge investigation of the function of Rapgef5 during craniofacial development.

Craniofacial birth defects are associated with over 700 human congenital syndromes, and are a leading cause of infant morbidity and mortality. However, despite their impact on child health, our understanding of how the head normally develops, and how these processes are disrupted in disease, remains limited. Discovering the genetic and cellular mechanisms that regulate craniofacial development is a critical first step towards improving treatment and patient prognosis. We recently identified the guanine nucleotide exchange factor Rapgef5 as an exciting new regulator of craniofacial development.

The successful candidate will use CRISPR/CAS9 mediated gene editing, state of the art imaging, genetic and molecular biology techniques to thoroughly investigate the function of Rapgef5 and generate new understanding of the mechanisms regulating development of the head.