Synthetic carbohydrates for the detection and prevention of infectious disease (FIELD_J18ICASE)
- Research Area Agriculture and Food Security
- Partner The John Innes Centre (JIC)
Professor Rob Field -
- Application Deadline 27/11/2017
In an AMR era, rapid diagnostics and alternatives to antibiotics to treat infectious diseases are urgently needed. Pathogenic microorganisms present a myriad of species-specific carbohydrate structures on their cell surfaces, which provide novel opportunities for detection and eradication. This project will explore the development of chemical and structural methods to produce and characterise cell surfaces carbohydrates found bacteria that are associated with diseases of farmed animals and that are also of concern from a bioterrorism perspective. The carbohydrates concerned will be further developed as probes to understand the biosynthesis of cell surface carbohydrates and as the basis of new diagnostics and vaccines.
The project will involve extensive engagement with the industrial partner, Iceni Diagnostics, which is co-located on the Norwich Research Park with the John Innes Centre. Previous experience in synthetic carbohydrate chemistry would be a distinct advantage, but full training will be provided.
This project comes with a £1500 per annum enhancement to the RCUK level stipend from the Industrial Partner.