Structure and function of the accessory Sec system in gut symbionts (JUGE_Q18DTP)
- Research Area Bioscience for Health
- Partner The Quadram Institute Bioscience (QIB)
Dr Nathalie Juge -
- Application Deadline 27/11/2017
The human body harbours a diverse and dense population of commensal bacteria, which exerts key functions in terms of nutrition and health. However, the precise mechanisms of how our beneficial intestinal microbes interact with the host remain largely unknown. In this project, you will use a trans-disciplinary approach including structural biology, molecular microbiology, glycobiology and animal models to decipher the pathways dedicated to the secretion of glycosylated adhesins by gut symbionts and their role in colonisation and biofilm formation.
This PhD project will provide mechanistic insights into host-microbe interactions in the gut and help rationally design probiotic-based strategies to promote human health and fight against infection and antimicrobial resistance.
The PhD student will join a dynamic and expanding Group working in the area of gut bacteria-host interaction at Quadram Institute Bioscience and benefit from complementary expertise on X-ray crystallography at the University of East Anglia. The PhD student will receive expert training in bioinformatics, molecular microbiology, structural biology and glycobiology.
This project will benefit from the established network of international collaborations in these research areas. Training will embrace research practice and theory, management, communication (to scientific and lay audiences), intellectual property, teamwork and technical writing. The student will present his/her work to internal seminars and to relevant International meetings. The possible commercial issues relating to the impact of this research on human health will be highlighted and the student will be encouraged to participate into outreach activities.