Resisting antimicrobial resistance: developing new antibiotics (WILKINSON_J19DTP1)
- Research Area Bioscience for Health
- Partner The John Innes Centre (JIC)
Prof Barrie Wilkinson -
- Application Deadline 26/11/2018
The discovery & development of penicillin sparked ‘The Golden Age of Antibiotics’ which spanned the 1940’s to 1960’s when most major classes of antibiotics were discovered. Indeed, the majority of antibiotics in clinical use today are derived from natural products made by microorganisms.
Alarmingly, the pipeline of new antibiotics has dried up at a time when Antimicrobial resistance (AMR) and emerging new pathogens has made their discovery a matter of extreme urgency. AMR is an increasingly serious threat to global public health, but is an inevitable consequence of the use of antibiotics.
In collaboration with Prof Matt Hutchings (UEA) and Prof Tony Maxwell (JIC), the successful candidate with develop a new class of natural product antibiotics with a high barrier for the selection of resistant isolates. They will have access to cutting-edge research facilities within JIC and UEA as well as a stimulating research and training environment. They will be part of an interdisciplinary team and through the project they will gain an excellent foundation in natural products and synthetic chemistry, biochemistry, microbial biotechnology & x-ray crystallography. There will be opportunity to interact with industry and other research institutes.
The combination of skills and experience provided by this studentship will make the successful candidate highly employable in academia and industry.