How to build a biological decoder – dissecting calcium specificity in plants (MILLER_U18DTP1)
- Research Area Frontier Bioscience
- Partner The University of East Anglia (UEA)
Dr Ben Miller -
- Application Deadline 27/11/2017
Calcium is one of the most common secondary messengers involved in cell signalling in plants. A first response to a vast array of abiotic and biotic stresses includes changes in cytosolic calcium concentrations that regulate downstream processes. That so many processes seem to be governed by the change in the concentration of calcium has given rise to what has been called the calcium specificity problem: how can one ion species be responsible for conveying such diverse developmental processes and differentially active different pathways?
The aim of this PhD project is to develop a deeper understanding of how calcium signals are interpreted by cells and decoded into specific biological responses in plants. The project will focus on the calcium-dependent protein kinase signalling network in the model plant Arabidopsis thaliana, and will study the mechanism by which calcium-dependent protein kinases are regulated by calcium and how this allows the decoding of specific calcium signals.
This project will combine molecular biology, biochemistry and mathematical modelling, and will provide the student with excellent opportunities for multi-disciplinary training in plant molecular genetics and biochemical techniques, as well as computational modelling approaches.