Does cellular migration induce DNA damage and accelerate vascular ageing? (WARREN_U19DTP)
- Research Area Bioscience for Health
- Partner The University of East Anglia (UEA)
Dr Derek Warren -
- Application Deadline 26/11/2018
Vascular smooth muscle cells (VSMCs) line the blood vessel wall and enhanced VSMC migration is observed during ageing and disease. Under normal conditions, VSMC secrete proteases to aid migration through the extracellular matrix (ECM). However, as we age, our blood vessels stiffen and display properties similar to bone. In these conditions, VSMCs can no longer degrade the ECM and the pressure of squeezing nuclei through this ECM can potentially cause DNA damage and premature VSMC senescence.
In this PhD, you will investigate and identify novel mechanisms that regulate VSMC migration. This research holds therapeutic potential that provide novel targets to manipulate early VSMC senescence observed in cardiovascular disease. During this interdisciplinary project, you will gain extensive experience in silica biomaterial fabrication alongside a wide range of biochemistry and cell biology techniques. These range from, but are not limited to, qPCR, Western blotting, immunofluorescence microscopy and transfection. In addition, you will have the opportunity to be trained in advanced microscopy techniques and multiple bioimaging analysis programs.