Projects

Recruitment to the NRPDTP and iCASE programmes are now open. The deadline for applications is the 27th November 2017.

02 / 10 / 2017

Computational modelling of information transfer between cells (MORRIS_J18DTP)

how to apply

Biology is the new physics. Biology is arguably generating some of the most interesting and relevant scientific challenges of our time and mathematical, physical and computational approaches are key to understanding biological complexity. Cell-to-cell communication is fundamental to multicellular organisms. The exchange of information and resources between cells and tissues enables co-ordination of responses to environmental and developmental signals. In plants, the cytoplasm of adjacent cells is connected by intercellular ‘tunnels’ that cross the cell wall, allowing for the exchange of molecules. These tunnels can regulate traffic between cells which is of particular importance during pathogen attack. Yet how this information flow is regulated remains largely unknown.

Using computational models this project will unravel of how molecules are transported from cell to cell to shed light on the mechanisms that underpin information flow within plants. The successful applicant will be part of an interdisciplinary team working on cell signalling, with leading researchers in mathematical systems biology and plant cell biology. This project is well suited for someone with a physics, maths or computing background who has an interest in biology or a biologist with strong numerical skills. The student will receive training in state-of-the-art microscopy, systems biology and numerical simulation methods for studying complex spatio-temporal problems.