Cannibalism in the early life microbiota; exploring the role of cross-feeding for modulation of microbial communities and immune cell responses. (HALL_Q19DTP2)
- Research Area Bioscience for Health
- Partner The Quadram Institute Bioscience (QIB)
Dr Lindsay Hall -
- Application Deadline 26/11/2018
We are looking for a creative and euthanasic PhD candidate to join a dynamic, multi-disciplinary research team investigating the interactions of the host with the intestinal microbiota during the early life developmental window. The Hall lab has 3 main research themes including, microbe-diet interactions, microbe-host cross-talk, and colonisation resistance. For more details visit www.halllab.co.uk.
The Hall lab is based within the Quadram Institute, a new interdisciplinary microbiome and food research Institute (www.quadram.ac.uk), thus providing an excellent platform for a starting scientific career.
Background: Our bodies are home to complex microbial communities, termed the microbiota, which are fundamental for host health. During the first stages of life our microbiota is dominated by the microbiota genus Bifidobacterium, and high levels of this pioneering microbe is commonly associated with improved infant wellbeing. Previous work in the Hall lab has suggested that specific components expressed by bifidobacteria may act as additional nutrient sources for community re-structuring and that metabolites produced positively influence immune cell maturation.
The goal of this PhD studentship is to use biochemistry, microbiology and bioinformatic techniques, in combination with immune cell analysis, to identify mechanisms underlying bifidobacterial metabolite cross-talk with the wider microbiota and the host. This project also involves close collaboration with other research groups on the Norwich Research Park; Prof Field (John Innes Centre) and Prof Murrell (University of East Anglia) and Dr Korcsmaros (Earlham Institute).