A mouse model to study a novel pathway for the control of influenza virus infection (WILEMAN_Q19DTP)
- Research Area Agriculture and Food Security
- Partner The Quadram Institute Bioscience (QIB)
Dr Thomas Wileman -
- Application Deadline 26/11/2018
The recent outbreaks of avian influenza and the threat of a human influenza pandemic has highlighted the need to understand prevention and control of this virus by developing effective antiviral therapies. We have recently shown that influenza virus is taken up into cells by a novel pathway called LC3- associated phagoytosis (LAP). We have developed a mouse model defective in this pathway, and this project will investigate the effects on virus replication and host innate immune responses after this pathway has been compromised in a transgenic mouse. Aberrant host defence leading to inflammatory disease may account for some of the pathological changes seen in this disease. Respiratory virus infections are of global significance to both the human and animal populations and this is an excellent opportunity to become involved an important area of human and veterinary interest. At the Quadram Institute, you will have access modern fully equipped laboratories with state of the art facilities of confocal microscopes, and in vivo imaging techniques. There is a large community of PGR students around Norwich Research Park and a wide number of opportunities for personal and professional development.